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by Patrick Arnold
Pat is responsible for launching several major product and innovation in the prohormone industry
through LPJ Research and
Ergopharm, including the first to release androstenedione, 1-AD, 6-OXO, 4-androstenediol, and 19-norandrostenediol. In addition, he is responsible for bringing innovative delivery systems to the prohormone market including HPB cyclodextrin, bioadhesive technology for sustained release, and sustained release sprays.
Publication Date: November 22, 1999
Norephedrine and PPA
Is there a difference between
Norephedrine and Phenylpropanolamine or are they one and the same?
There seems to be a trend among the fat burning supplements to get
away from ephedrine containing compounds towards the former
mentioned product. Is there any valid research showing norephedrine
to be an effective thermogenic agent? Thanks a million!
Craig
Both names describe the same compound(s). It is important to
know that there are two different optical isomers of this compound.
The synthetic stuff is a racemic mixture - dl-norephedrine and the
natural stuff that Syntrax sells I think is straight l-norephedrine.
Though I am not completely sure. Derek Cornelius would be the one
who knows more than myself probably
Dianabol and Drug Testing
Dear Mr. Arnold,
My friend was on a type of steroid he
calls D-bol. I have been working out with him for the last 5 month
since he started. His results are amazing not only in size but more
in the strength department. What is the medical name for it?
Second, I am a utility worker and on any
given day, I will work on 200 or 50,000 volts, so drug testing is
random and very frequent. To my knowledge, they check for drugs
like cocaine, marijuana, etc. Will this type of steroid show up in
my urine say if they were looking for the other stuff. Is there any
way to manipulate it . Also heard it can cause severe liver damage.
Thank you so much for your time.
Seth
Seth, your friend is taking a steroid called Dianabol, or
generically known as methandrostenolone. It is referred to as D-bol
for short. This anabolic steroid is perhaps the most well known and
abused of all steroids from the 1960's on. It was, for a long time,
the standard bodybuilding drug used by athletes. It is a very
effective compound however there is a slight risk of liver toxicity
when it is being used due to a synthetic chemical alteration from
normal testosterone to make it orally active.
I doubt your company screens for steroids when they analyze your
urine. It is just too expensive and besides what they are really
interested in is anything that will interfere with your awareness
and reactions, not your muscle girth.
Prohormone Enzyme Saturation
How much prohormone can one enzymatic
pathway handle before the enzyme is used up and the excess
prohormone becomes wasted? Also, how long before the enzymes are
back to normal levels in the liver? In other words, how much 4-AD
can be taken at one time and how often throughout the day should it
be taken?
Unfortunately we still do not know at what dosage a saturation of
receptors is reached with any of the prohormones. It certainly seems
that the threshold is much higher with 3beta-HSD (transforms the
4-diols) than with 17beta-HSD (transforms the 4-diones). I have
heard of dose dependent increases in effects up to a few grams a day
with the diols, so it may be that either a saturation is not being
reached OR unchanged diol is exerting a direct anabolic/androgenic
effect.
Saw Palmetto - Good or Bad?
Is Saw Palmetto a good idea to take or
is it detrimental? I have heard conflicting reports.
I still don't know if it has an adequate risk to benefit ratio.
On the good side some evidence shows it may act as an anti-estrogen
and a 5alpha reductase inhibitor (blocks formation of DHT).
However, some evidence also demonstrates an androgen receptor
blocking property and that is something we certainly do NOT want.
So the evidence is inconclusive.
Norandrodiol for Joint Pain
Mr. Arnold,
Does 19 Norandrodiol impart the same
effect of easing joint pain as Deca? I have chronic elbow pain that
only gets relief when on a Deca cycle. If the prohormones can
illicit the same effect, what dosage is needed per day and which
Substrate Solution "Nor" product would be the most effective? Thanks
very much for the info.
Sincerely,
John
I have heard this deca / joint pain thing for years now and if there
really is anything to it I cannot figure what it could be. If it
had some glucocorticoid activity this would make some sense but it
certainly does not. Also, if it had prostaglandin synthesis
inhibitory activity similar to NSAIDS like aspirin and ibuprofen,
then I could understand it but I see no indication that this is the
case. Anyway, if there is something unique to the nandrolone
molecule that allows it to alleviate joint pain then I would expect
you would see this effect whether you delivered the substance thru
an injectable ester or a prohormone.
Effectiveness of Miscellaneous Supplements
Hi Patrick,
Hoping you could give me your brief thoughts of the effectiveness of
the following supplements:
- Vanadyl Sulfate
- OKG
- HMB
- CLA
- Digestive Enzymes (for
inflammation)
I truly appreciate your thoughts.
Thanks!
Kirk
Jeez, this letter must have been stuck in the mail for 3 years.
Anyway,
Vanadyl Sulfate is in my opinion a waste of time, and possibly
counterproductive. I have read studies where while it does share
some of the glucose transporting properties of insulin, it might not
exert any of the positive effects of insulin on protein metabolism.
Also the glucose deposition in one study with rats showed that the
liver was way too overpreferred for storage compared to muscle.
OKG: OKG was something that showed a lot of promise because
of its effectiveness as an anti-catabolic nutritional supplement for
critical care patients with marked negative nitrogen balance.
However, the stuff did not pan out with well nourished untraumatized
bodybuilders who got nothing from the stuff except a case of the dry
heaves when they opened the bottle.
HMB: HMB was a victim of shameless hype. It was an
interesting nutrient that should have been introduced in a low key
manner, reflecting its modest capabilities. However the marketing
Godzilla of bodybuilding at the time raised all sorts of
unreasonable expectations for the stuff which eventually spelled its
death in the eyes of the consumers. HMB might have some marginal
positive effects on protein metabolism and fat redistribution,
however given its high cost it is usually not the place where ones
limited budget should be going.
CLA: CLA, at least in its present form, seems to be a big
dissapointment as well. The commercial oil remains too expensive
and not enriched enough for effective usage (if it is effective at
the higher dosages). There also is some recent indication that the
c9,t11 isomer may not be the most active, but rather the c10,t12.
Who knows.
Digestive Enzymes: As far as digestive enzymes counteracting
inflammation I don't think that is what they would do. Rather, I
would think they might irritate any sensitive areas of your gut if
anything.
Boy you really made a complete list of some of the biggest
supplement bombs of the last five years. Is someone trying to sell
you a bunch of surplus supplements they can't get rid of or
something?
Effective Anti-Estrogens
Hello Mr. Arnold,
I am wondering is it necessary to take
an anti-estrogen like chrysin with androstenedione? I read it is not
necessary to take anti-estrogens with Androdiol. Is this true?
Finally what side effects and effects would be encountered taking
Dianabol (2 tablets) daily for 6 weeks and then off for 6 weeks. How
could the side effects be eliminated? Thanks again Mr. Arnold
Androstenedione differs from androdiol in chemical structure in such
a way that the former can aromatize fairly easily while the latter
cannot aromatize directly. Therefore estrogen is much more of a
problem with androstenedione than 4-AD (androdiol). So many do not
find it necessary to take an anti-estrogen with androdiol.
My friend did a study on rats with chrysin that seems to support the
fear that the stuff does not inhibit estrogen production at
reasonable dosages. There really is no super promising natural
anti-estrogen out there except for I3C (or better yet
diindoylmethane).
I don't think a whole lot would be gained from 10mg a day of
Dianabol, unless you are a first time user with high sensitivity.
You could get acne, gyno, and water retention as most common side
effects.
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