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by Patrick Arnold
Pat is responsible for launching several major product and innovation in the prohormone industry
through LPJ Research and
Ergopharm, including the first to release androstenedione, 1-AD, 6-OXO, 4-androstenediol, and 19-norandrostenediol. In addition, he is responsible for bringing innovative delivery systems to the prohormone market including HPB cyclodextrin, bioadhesive technology for sustained release, and sustained release sprays.
Publication Date: February 15,
1999
Counteracting Prednisone with Prohormones?
I'm 17, and have had a condition called ulcerative colitis
(brother/sister to Crohn’s) for approximately 6 months. I'm
currently taking a large oral dose of prednisone (catabolic cortisol
steroid), which sucks. I'm considering going on some kind of Nor
stack (probably diol) to try to counteract the catabolic properties
of prednisone. I'm curious if anyone else has done or heard of
someone doing the same thing? I would do it in a heartbeat if I was
older, but the fact that I'm 17 and that I'm stupid in this respect,
doesn't help. Does anyone know if it blocks certain prednisone
receptors? I don't want the Prednisone to stop doing its job (the
benefits) I just want to try to lower the catabolic side of it. Any
help is appreciated.. Thanks.
Christ you do not want to block the receptors for prednisone. If
you did then what would be the point of the prednisone. Do not
worry, anabolic steroids do not have a binding affinity to
corticosteroid receptors of any biologically significant degree.
Don't have the reference handy but unless you want to take
methyltrienolone I think you are pretty safe here.
It is a good thing that you are taking anabolic drugs to
counteract the catabolism of the coricosteroids without interfering
with their anti-inflammatory effects. A lot of research was done in
the past that showed anabolic steroids, taken in conjunction with
corticosteroids, did not interfere with the desired therapeutic
effects and yet they did significantly mitigate (though not
completely eliminate) the undesired protein catabolic effects.
Growth Hormone and IGF-1 have also been shown to be beneficial in
combating corticoid wasting.
It is important to remember that none of these agents BLOCK
cortisol per se (as has been incorrectly hypothesized by certain
leap before they jump fool-rus), instead they work to antagonize
some of the metabolic effects that cortisol stimulates. These
metabolic effects concern protein balance and fortunately not the
prostaglandin mediated anti-inflammatory activity. (The AI effects
of corticoids does involve prostaglandins, doesn't it?)
Difference Between Clomiphene and Tamoxifen
Someone said I could take Clomid for gyno. I thought Clomid was
just for raising LH by stimulating the HPTA and tamoxifen was for
gyno. What gives?
Clomid is actually an anti-estrogen related chemically to
tamoxifen Rob. And its HPTA stimulatory action is probably a
function of its blocking estrogen receptors at the hypothalmus. It
was never marketed as such though but it could have been. That’s OK
Pete, we will let you slide on this one, its one of those things
where you got to be a pharmaceutical reference book and library buff
to be familiar with.
BTW the partial estrogen (or is it full anti-estrogen)
droloxifene has a patent on it for elevation of testosterone levels.
However I think that when people elevate their test levels with
these anti-estrogens alone they don't find the effects they should.
I believe that’s cuz some of testosterone’s action requires a
certain quantity of simultaneous estrogen. For instance, you
eliminate estrogen and your growth hormone levels can take a nose
dive.
Aromatase Inhibitors vs. Anti-estrogens
How do aromatase inhibitors compare with the receptor
anti-estrogens?
Aromatase inhibitors are probably superior to both in regards to
overall effects on anabolic hormones. Nolvadex and Clomid both have
estrogen agonist effects on the liver and therefore serve to
decrease serum IGF-1 blood levels (most of which is of hepatic
origin). They may also have the effect of increasing SHBG which
most people consider a negative though mad scientist MDGADPC and the
ever more esoteric Dan Duchaine have presented arguments otherwise
(I still am in the former camp).
Cytadren (and other aromatase inhibitors I would assume as well)
have no estrogenic activity and therefore one actually sees a net
rise in IGF-1 levels in women that take it compared to Nolvadex and
some other receptor antagonist that show net decreases.
Of course the soon to be available pure anti-estrogens are still
an unknown.
Tribulus, LH, and Testosterone
Dear Pat,
I am doing my masters' thesis on the effects tribulus terrestris has
on LH and testosterone levels in the human body. However, my efforts
to find relevant literature (a must for a lit review in a thesis) is
frustrating, to say the least. All the information I found was done
in Bulgaria in the early 1980's, and most of it is in Bulgarian,
which I don't read. If you have any professional advice for me, I'm
all ears.
Joe, California State University, Chico
Joe, I feel your pain. I myself have done literature searches of
terrestris extract and found very little information except for
things such as increased fertility and sexual activity in animals.
I hear from the grapevine though that a reputable researcher is
going to perform a study using the Sopharma brand "Tribestan" to try
to duplicate the positive results on LH and testosterone that the
makers claim in their unpublished data.
So be patient and you may have to find another thesis subject.
Applying AndrosteDERM
I just bought some AndrosteDERM. Based on a big libido increase
after trying it I think it must be working well. The problem I have
with it is they want you to rub it on the inside of your thighs and
I lack the hair free area to put it on lightly as they say. (They
say all hairy areas are a no no.) I would like to be able to put it
on another area like, lets say, the inside of my forearms. That area
is not hairy and seems to be thin skinned (their criteria). Please
tell me if this is good or where I should rub this stuff.
Your forearms would be good but do not offer much surface area. Look
mister, if you want to be serious about something you have to make
some sacrifices. God forbid you may have to shave your torso or legs
to give yourself a nice area to rub it on. Or if you already have a
small bald spot then rub it there and be sure to hit the edges of
the spot. Before you know it you may have a whole cranial area of
administration!!
How much Androdiol?
Mr. Arnold,
I am a bodybuilder using some Androdiol from Substrate Solutions and
am curious as to what dosage you personally recommend people take.
Are the prohormone dosages a function of bodyweight? Since my own
weight varies between 275 and 295, I usually have to double (or even
triple ) the dosages of medicine I take compared to the "standard"
recommended dosages meant for normal people. Thanks for your time
and for developing a product which, according to all accounts, is
one of the first truly effective supplements ever produced.
TJ
Its tough to prescribe over email but I would say take 600 to 1200mg
a day in 3 divided doses
Cyclodextrin versus Sublingual Prohormone
Administration
My question is about the SCC I have 100mg of
19-Norandrostenediol and 100mg of 4-Androstenediol that I take can I
take half the dose under my tongue and get the same effects that the
SCC will do? Could you tell me the best way to take the pro hormones
that I have?
Straight prohormones do not have very good absorption under the
tongue. When complexed with cyclodextrin the properties change to
enable it to absorb extremely well. It would be a long and detailed
explanation but that is the jist of it.
Cyclodextrin vs. Injectable Androdiol
Hi Pat, I read an article about using cyclodextrin to increase
the Availability of andro and a sentence how an injectable andro
would increase the bioavailability to almost a 100%. I've been
looking all over for something that might shed a little light on
formulating an injectable form from the oral form but I've been
unsuccessful in finding anything. I was just wondering if you could
"hypothetically" shed a little light on how one would go about
formulating such a thing. Great column! I very much enjoy reading it
daily. Keep up the great work!!
Syntrax is coming out with a transdermal suspension which is
supposed to have characteristics that would make it a suitable
injectable but I have nothing more to say about that.
Propecia and Deca Durabolin
Dear Mr. Arnold,
In your answer to Propecia and prohormones I see that you say
Propecia and Norandrodiol will cause more hair loss. I am wondering,
would the same happen to a person taking the real stuff - Deca?
Thanks for your time. I am hoping to hit my Deca cycle on January
1st and would like your help.
Yes, it works that way with all 19-nors with the exception of a
subclass that is not available anyway.
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