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by Patrick Arnold
Pat is responsible for launching several major product and innovation in the prohormone industry
through LPJ Research and
Ergopharm, including the first to release androstenedione, 1-AD, 6-OXO, 4-androstenediol, and 19-norandrostenediol. In addition, he is responsible for bringing innovative delivery systems to the prohormone market including HPB cyclodextrin, bioadhesive technology for sustained release, and sustained release sprays.
Publication Date: August
1998
Dear Pat,
I have been told that Substrate
Solution's Norandrostenediol is the ineffective 19Nor-5androstene-3,
17Diol version and not the 19Nor-4 androstene-3, 17Diol version. Is
this true?
Answer:
You have it backwards. Substrate Solution's norandrostenediol is
the delta-4 version, the good and proven effective compound. I
supervise the production of Substrate's norandrodiol and I can vouch
that it is of the highest purity and potency of any
norandrostenediol available on the market today.
Dear Patrick,
If someone were to take
norandrostenediol with norandrostenedione, would it increase the
amount of nandrolone in the body? Do they use the same enzyme? Is it
true that nandrolone stays at the receptor for 4 days?
Answer:
Both norandrostenediol and norandrostenedione, taken separately
or together, will raise the amount of nandrolone
(19-nortestosterone) in the bloodstream. These two precursors
utilize different enzymes in the process of their conversions so
theoretically they should make a good stack. The rumor about
nandrolone staying at the receptor for 4 days is completely
ludicrous and whoever said this obviously has a poor understanding
of biology. Nandrolone should have a lifetime in the bloodstream
similar to testosterone.
Dear Pat
I have a question pertaining
19nor-androstenediol: Is this product available with both versions -
4ad, 5ad? In you opinion, which would you say is better? Also, are
there any ways or products that you would suggest stacking in
conjunction with these supplements to increase the possibility of
effect? I would value your opinions, descriptions, or any findings
you would care to share.
Answer:
19-norandrostenediol is available in two forms. First is the
delta-4 (delta "X" refers to the position of a double bond on the
steroid backbone) version also known as norandrodiol or Bolandiol.
This version is the one which has ample scientific literature
confirming its biological (anabolic) activity and is also the
version which was once sold in foreign countries as an anabolic
steroid.
The other form is the delta-5 version. The delta-5 is a mystery
compound, there is no evidence in the literature of any biological
activity for this stuff. I have tried to get the sellers of this
compound to provide me with some proof of its efficacy but they
would not respond. I cannot for the life of me figure out why anyone
ever bothered to have this stuff made.
I would recommend stacking the delta-4 (norandrodiol) version
with a testosterone precursor like androstenedione or better yet
androdiol. That way you get the benefits of a strong androgenic
component to complement the mostly anabolic norandrodiol.
Dear Patrick,
I would like to ask you how to use
GrowthHormone (GH) and Insulin. I've heard that I can make great
progress with these products, but my knowledge is not enough to use
it properly. They advised me to use 4-8 IU of GH a day
(somatrophine). How much insulin do I have to use with this many
IU’s of GH? My current bodyweight is 242 lbs.
Answer:
I would advise you not to use insulin at all as it is a
potentially dangerous compound for non-diabetics to fool around
with. However I can tell you what I know about its usage in
conjunction with GH for bodybuilding purposes. A daily dosage for
Humulin R in combination with the dosage of GH you mention would be
10 to 20 units a day. The GH is best taken about 30 minutes to an
hour after the shot of Humulin R; this is so the GH reaches your
bloodstream at the same time that the insulin is peaking so the
IGF-1 response is maximized.
Dear Pat,
I came across an article from "USA
Today" on an internet search. The article said that the US Olympic
Committee asked the FBI to investigate Price Power's advertisement
of the "banned steriod androstenedione". My concern is that this is
the first step to banning all pro-hormones from over the counter
use. Has the FDA issued an opinion regarding androstenedione,
androstenediol, 19-norandrostenedione and 19-noranrdostenediol? The
article can be found at:
http://web.archive.org/web/20010210190436/http://www.usatoday.com/life/cyber/tech/ctb757.htm
Thank-you
Answer:
I think what happened was the FBI investigated and then found out
that the FDA has no prohibitive policy against androstenedione and
the matter was put to rest. The FDA has no opinion that I know of on
any of the hormone precursors. According to the DSHE act these
products should be legal for sale unless the FDA can prove them
unsafe for consumption, and since androgenic steroids really have no
acute adverse affects (although they do have chronic adverse
affects) it would be almost impossible for the FDA to show any time
soon that these products are dangerous.
Dear Pat,
You wouldn't know real science if it
fell out of the sky and landed on your head. I guess the over 2000
physicians dispensing PRO-hGH are all idiots and you're the only
smart person on earth. Must be lonely at the top. There's nobody
developing sports performance products with credentials even close
to those of James Jamieson, the developer and patent holder of
PRO-hGH. He holds over 170 patents in medicine and Nutraceuticals,
especially in delivery systems. He developed "patch" technology
which is used by many pharmaceutical companies now. He doesn't
release a product unless it works. Many clinical studies verified
PRO-hGH before its release. The product works, it works better by
far than any other similar product, so get over it.
Answer:
This letter is from a representative of VesPro, the company that
distributes the supposed GH increaser Pro-hGH. It is in response to
a posting I made on mfw in which I reported the results of an
independent physicians findings that the product was ineffective in
raising blood levels of GH and IGF-1.
This person's only recourse is to reiterate the credentials of
the physician who invented the product. Well I have news for you,
even those with impressive credentials can do dishonest things. And
it appears to me that something very sleazy and dishonest is going
on with this product.
The physicians claim that they have discovered a natural GHRP
(growth hormone releasing peptide) but all the credible literature
to date claims that the natural ligand for the GHRP receptor has yet
to be identified. They say this natural GHRP is the core ingredient
of their product yet they do not list it in the ingredient label and
they do not reveal its amino acid sequence. Another mystery is why
(if they are truly scientists) did they never publish their findings
after the "discovery" of this NGHRP, which by the way would be a
major breakthrough in the field of endocrinology. Still another
mystery is why they did not try to license their findings to the
pharmaceutical industry where they could have made infinitely more
money than the supplement industry. These people talk about
"clinical studies" but strangely enough none of these have ever been
published in any reputable peer reviewed scientific journals.
This man is right, I have nowhere near the credentials of this
mysterious Dr. Jamieson (funny how I just did a US patent search on
his name and came up with 0 hits) but I do have a nose on my face
with which I can smell rats.
Mr. Arnold,
I was intrigued by what you said about
DHT increasing aggressiveness and possibly having an anabolic
effect. I am a 22-year-old College Wrestler, and a 2x All-American
(3rd in Nation). I have recently started taking Propecia to stop
hair loss. So would your advice be to quit taking the Propecia when
the season starts (I need all the aggressiveness I can get in this
sport) or to even quit taking it altogether until my athletic career
is over? Also, how likely is Androstenediol to cause more hair loss
compared to 5-AD?
Finally, will taking these prohormones
make me flunk an NCAA drug test? If so, how long to I need to quit
taking them before I am tested? Thanks Patrick.
Justin K
Answer:
I would strongly recommend stopping the Propecia for the duration
of the wrestling season to optimize androgenic CNS effects. When the
season is over you may resume the Propecia if you feel it is needed
to combat your balding problems.
4-androstenediol is a much better precursor to testosterone than
5-Androstenediol so it should thereby increase DHT levels to a
higher extent and exacerbate hair loss more.
Testosterone precursors will not (well, should not) make you
flunk a drug test if discontinued 48 hours prior to testing.
19-Nortestosterone precursors should always be avoided for anyone
subject to doping testing.
Dear Patrick,
Hello I love your articles though I
hardly understand them are there any books on these prohormones that
you talk about that I can read to educate My self on these
matters??? I want to buy your Supplements from Substrate Solutions
but I have a question or two I hope you can help me with.
- Which is the most Powerful stack
you offer???
- Can I take saw Palmetto Berry
extract to prevent DHT from enlarging my prostate or causing
hair loss and how much??? Plus who makes a good brand of Saw
Palmetto berry extract ???
- I'm concerned about testosterone
elevations increasing estrogen production. You mentioned chrysin
which I hear doesn't work in humans. I been asking around about
Ipriflavone and people look at me like I'm nuts. What is it
and who sells it and where can I get it??? Please reply - I
really need help on this. Thanks for your time and keep up the
great work :-)
Answer:
There really aren't any books on prohormones. All I learned on
the subject came from journals and highly technical biochemistry
books. IMO the strongest product that Substrate Solutions offers is
the Diol Stack.
You can take Saw Palmetto to protect your prostate and possibly
reduce hair loss however be aware that because it is anti-androgenic
in nature the stuff may cut into your gains.
I did not say that Chrysin absolutely did not work in humans,
rather I said that in-vivo efficacy has never been proven and that I
suspect that if it does work in humans the dosage would be
prohibitively high.
Ipriflavone, despite the misinformation that has been spread
about it, is not an anti-estrogenic compound. Rather it is an
isoflavone derivative with no hormonal activity that exhibits
anabolic activity on bone and possibly muscle.
Dear Patrick:
I've heard a lot about Pump 'n Pose
(quite a few different stories) and I'm not sure what to believe.
Could you please tell me what it does and how it's taken? Obviously
for $400 it is more than an oil you put on and it gives you a pump
for a little while. Thank you for your prompt response!
Answer:
Pump'n Pose, also known as Synthol, is an injectable oil
preparation with the intended use for temporarily swelling up
individual muscle groups (i.e. biceps, calves). A year or so ago Dan
Duchaine sent me a sample of this stuff and I had it tested. The
results showed that this esoteric mystery liquid was nothing but
ordinary MCT oil (also contains lidocaine and a bit of alcohol).
Obviously someone has a HUGE profit margin if they are bottling
100cc's of MCT oil and retailing it for $400.
If you are adamant on experimenting with Synthol then I would
recommend buying some MCT oil (Captri from Parillo is fine) and
injecting it directly. Say for instance 5cc's in each bicep. That
way you will have satisfied your curiosity and not drained your bank
account in the process.
Dear Pat,
I just read where you said "I am
skeptical if there is any synergism between the diones and the diols,
and knowing how much more potent the diols are I simply say spend
your money on them." What is a 'diol' and what is a 'dione'
...please explain . I really would appreciate an explanation from
you, since I have just become acquainted with your works and
writings. Thank you very much!----Mhayes
Answer:
The terms diol and dione are chemical terms that refer to certain
structural characteristics of a molecule. Specifically diol means
the molecule has two hydroxyl groups (di=two, ol=hydroxyl). The term
dione means the molecule has two ketone groups (di=two, one=ketone).
Probably the most important structural characteristic of active
androgens is the 17ß-hydroxyl group. This group is present on the
diols but not on the diones and this explains why the diols display
a significant degree of intrinsic (before conversion) activity while
the diones do not.
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